The concept of Safe-by-Design aims to integrate safe manufacturing, safe production and responsible waste management in the innovation process at the earliest possible. Safe-by-Design requires a timely dialogue between relevant stakeholders. Within NanoNextNL the concept of Safe-by-Design was further developed within the Risk Analysis and Technology Assessment theme (RATA) and applied in the Valorisation Programme.
Safe-by-Design tools for research and development
NanoNextNL developed unique Safe-by-Design tools ready for application in research and development:
- Safe-by-Design tools for researchers and technology developers
- Safe-by-Design tools for starting entrepreneurs
- Safe-by-Design tools for entrepreneurs
- Safe-by-Design tools for interaction with society
Safe-by-Design tools for researchers and technology developers
Technology assessment tools for researchers and technology developers: Toolbox Constructive Technology Assessment
With these tools insights into the economic, societal, ethical and legal aspects can be gained at an early stage in the development process. The tools are classified according to the development stage and applications. For more information: www.cta-toolbox.nl
Safe-by-Design tool for starting entrepreneurs
As part of the NanoNextNL Valorisation Programme business case owners have been asked to perform a Safety and Society Check.
Starting entrepreneurs used the following questionnaire to execute the Safety and Society Check : RATA questionnaire Valorisation Programme (pdf)
Safe-by-Design tools for entrepreneurs
The Golden Egg Check, an online tool used within the NanoNextNL Valorisation Programme, was extended with risk analysis and technology assessment.
Entrepreneurs used the following questionnaire for a Safety and Society Check as part of the Golden Egg Check: RATA questionnaire Valorisation Programme (pdf)
Safe-by-Design tools for interaction with society
Safe-by-Design intends to stimulate representatives from business, science, government and civil society to discuss societal responses and challenges tot nanotechnology. The Societal Incubator is used as an experimental tool to explore the sentiments of involved stakeholders and is under construction.
A new type of sensor has the potential to replace sniffer dogs when it comes to detecting explosives such as TNT. This week, researchers from a number of institutions including TU Delft are publishing an article about this subject in the American Chemical Society’s journal Nano Letters. The research in Nano Letters was also supported by NanoNextNL and NWO.
‘For the first time ever, we have used molecules with a lantern-type cage structure to fabricate sensitive nanosensors that can detect explosive substances such as TNT’, says researcher Louis de Smet (affiliated with TU Delft and Wageningen University).
‘These cage structures have a capacity of about 1 cubic nanometre, which precisely accommodates a single TNT molecule.’ Researchers from TU Delft, the University of Twente, Philips Research, the City University of Hong Kong and the University of Melbourne have chemically bound an ultrathin layer of these specially developed cages to the surface of a sensor chip containing a few dozen sensitive nanosensors. A single cage is not sufficient for detection purposes.
‘Porous molecules are used quite often to capture ambient molecules’, explains De Smet. ‘In the case of relatively small molecules, as with explosives, the challenge is to ensure that the cage structure is not only the right size but that it also has the right anchor points so that the molecule can click into place – thus rendering it detectable. For this work, we therefore use layers consisting of so-called MOP molecules (Metal-Organic Polyhedra). Through variation with a large number of geometric and electronic properties of these complex cage molecules, we are able to capture the ‘explosive’ molecules we are looking for. And the presence of such a molecule also causes the electrical conductance of the underlying silicon nanowires to change in a very characteristic way. We can measure this and thus confirm that we have actually found TNT molecules from an explosive.’
‘Eventually, we may be able to use this type of sensor to detect explosives – in a war situation, for example, or when facing a terrorist threat’, says De Smet. ‘Currently, very different, qualitative methods are mainly used for this, involving chemical reactions causing colour changes, for instance, or the deployment of sniffer dogs. The great thing about our method is that you can not only detect whether there are traces of TNT but you can also determine the amount.’
Mrs Cao, PhD candidate at TU Delft and Dr Zhu, postdoctoral researcher at the University of Twente initiated this work and performed the experiments, while Dr Shang did the computational work. Dr Klootwijk, Prof Sudhölter, Prof Huskens and Dr De Smet supervised the project.
The research in Nano Letters was also supported by NanoNextNL and NWO: Metal−Organic Polyhedra-Coated Si Nanowires for the Sensitive Detection of Trace Explosives. Anping Cao, Wei Zhu, Jin Shang, Johan Klootwijk, Ernst Sudhölter, Jurriaan Huskens, Louis de Smet, Nano Letters, 2016.
Source: Delft University of Technology